Medical Director
Senior Consultant, General & Colorectal Surgeon
MBBS (Singapore), MRCS (Edinburgh), MMed (Surgery), FRCS (Edinburgh)
There have been significant advancements in genomic information for colorectal cancer (CRC). Hereditary colorectal cancer syndromes are known to consist of 10% of all CRC but more than 20% of have family history with yet to be defined abnormal gene.
Also, while CRC tends to occur in the elderly, there are around 13-15% of CRC that can occur when one is less than 45 years old.
A young colorectal cancer patient or a patient with strong family history of colon cancer will have many concerns. Besides how best to manage oneself when a diagnosis is made, there are also worries of the risk to loved ones. Subsequently, there may be a need for genetic testing. In hereditary conditions, prophylactic surgery (surgery before developing colorectal cancer) may have to be conducted. Other organ systems may also have to be screened as concurrent cancers may develop.
Dr Chew Min Hoe has investigated extensively into various hereditary colorectal cancer syndromes and conditions. He has also reviewed and researched about young colorectal cancers in Singapore. He continues to manage many families with hereditary conditions and provides screening and surveillance.
Dr Chew Min Hoe
Medical Director
Senior Consultant, General & Colorectal Surgeon
MBBS (Singapore), MRCS (Edinburgh), MMed (Surgery), FRCS (Edinburgh)
Dr Chew Min Hoe is an experienced colorectal surgeon with a special interest in hereditary conditions, as well as minimally invasive procedures and advanced cancer treatments.
He was the founding Head of the Department of Surgery at Sengkang General Hospital and served as President of the Society of Colorectal Surgeons, Singapore. In 2020, he received the Public Administration Medal (Bronze) - a testament to his contributions to the field.
Chew MH; Koh PK; Ng KH; Lim JF; Ho KS; Ooi BS; Tang CL; Eu KW
Phenotypic characteristics of hereditary non-polyposis colorectal cancer by the Amsterdam criteria: an Asian perspective.
ANZ journal of surgery 2008; 78(7):556-560 (Article; Published in Print)
Chew MH; Koh PK; Ng KH; Eu KW
Improved survival in an Asian cohort of young colorectal cancer patients: an analysis of 523 patients from a single institution.
International journal of colorectal disease 2009; 24(9):1075-38 (Article; Published in Print)
Chew MH; Quah HM; Teh KL; Loi T T C; Eu KW; Tang CL
Twenty years of familial adenomatosis polyposis syndromes in the Singapore Polyposis Registry: an analysis of outcomes.
Singapore medical journal 2011; 52(4):246-251 (Article; Published in Print)
Chew MH; Koh PK; Tan M; Lim KH; C Loi; Tang CL
Mismatch repair deficiency screening via immunohistochemical staining in young Asians with colorectal cancers.
World journal of surgery 2013; 37(10):2468-2757 (Article; Published in Print)
Liu YQ; Chew MH; Goh XW; Tan SY; Loi Carol T T; Tan YM; Law HY; Koh PK; Tang CL
Systematic study on genetic and epimutational profile of a cohort of Amsterdam criteria-defined Lynch Syndrome in Singapore.
PloS one 2014; 9(4):e94170-N.A (Article; Published in Print)
Chew MH, Tan WS, Liu Y, Cheah PY, Loi CT, Tang CL.
Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis Registry.
Ann Acad Med Singapore. 2015 Aug;44(8):290-6.
Chua CS, Loi CTT, Koh PK, Cheah PY, Lee HY, Tang CL, Ngeow J, Chew MH
PTEN Hamartoma Tumour Syndrome: Gastrointestinal Manifestations of Two Cases Diagnosed in Singapore.
Hereditary Genet 2015 4:148. doi: 10.4172/2161-1041.1000148
Thean LF, Wong YH, Lo M, Loi C, Chew MH, Tang CL, Cheah PY.
Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.
PLoS One. 2017 Mar 17;12(3):e0173772. doi: 10.1371/journal.pone.0173772
W Tan, J L Hamzah, S Acharyya, Foo FJ, Lim KH, I Tan BH, Tang CL, Chew MH
Evaluation of long-term outcomes of microsatellite instability status in an Asian Cohort of Sporadic Colorectal Cancers.
J Gastrointest Canc 2017 May 27 doi 10.1007/S12029-017-9953-6
Thean LF, Low YS, Michelle Lo, Teo Y-Y, Koh W-P, Yuan J-M, Chew MH, Tang CL, Cheah PY
Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk
J Med Genet 2018 Mar;55 (3):181 188. doi:10.1136/jmedgenet-2017-104913. Epub 2017 Oct 27. PubMed PMID: 29079706
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Caring Hearts, Educated Minds, Skilled Hands
Orchard
3 Mount Elizabeth #16-09, Mount Elizabeth Medical Centre,Singapore 228510
Tel:+65 6518 4688
Fax:+65 6235 0897
Mon-Fri:8:30am - 5:30pm
Sat / PH Eve:8:30am - 12:00 noon
Sun & Public Holiday: Closed
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Tel:+65 6518 4868
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Sat / PH Eve:8:30am - 12:00 noon
Sun & Public Holiday: Closed
