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There have been significant advancements in genomic information for colorectal cancer (CRC). Hereditary colorectal cancer syndromes are known to consist of 10% of all CRC but more than 20% of have family history with yet to be defined abnormal gene. Also, while CRC tends to occur in the elderly, there are around 13-15% of CRC that can occur when one is less than 45 years old.
A young colorectal cancer patient or a patient with strong family history of colon cancer will have many concerns. Besides how best to manage oneself when a diagnosis is made, there are also worries of the risk to loved ones. Subsequently, there may be a need for genetic testing. In hereditary conditions, prophylactic surgery (surgery before developing colorectal cancer) may have to be conducted. Other organ systems may also have to be screened as concurrent cancers may develop.
Dr Chew Min Hoe has investigated extensively into various hereditary colorectal cancer syndromes and conditions. He has also reviewed and researched about young colorectal cancers in Singapore. He continues to manage many families with hereditary conditions and provides screening and surveillance.
  • Chew MH; Koh PK; Ng KH; Lim JF; Ho KS; Ooi BS; Tang CL; Eu KW
    Phenotypic characteristics of hereditary non-polyposis colorectal cancer by the Amsterdam criteria: an Asian perspective.
    ANZ journal of surgery 2008; 78(7):556-560 (Article; Published in Print)
  • Chew MH; Koh PK; Ng KH; Eu KW
    Improved survival in an Asian cohort of young colorectal cancer patients: an analysis of 523 patients from a single institution.
    International journal of colorectal disease 2009; 24(9):1075-38 (Article; Published in Print)
  • Chew MH; Quah HM; Teh KL; Loi T T C; Eu KW; Tang CL
    Twenty years of familial adenomatosis polyposis syndromes in the Singapore Polyposis Registry: an analysis of outcomes.
    Singapore medical journal 2011; 52(4):246-251 (Article; Published in Print)
  • Chew MH; Koh PK; Tan M; Lim KH; C Loi; Tang CL
    Mismatch repair deficiency screening via immunohistochemical staining in young Asians with colorectal cancers.
    World journal of surgery 2013; 37(10):2468-2757 (Article; Published in Print)
  • Liu YQ; Chew MH; Goh XW; Tan SY; Loi Carol T T; Tan YM; Law HY; Koh PK; Tang CL
    Systematic study on genetic and epimutational profile of a cohort of Amsterdam criteria-defined Lynch Syndrome in Singapore.
    PloS one 2014; 9(4):e94170-N.A (Article; Published in Print)
  • Chew MH, Tan WS, Liu Y, Cheah PY, Loi CT, Tang CL.
    Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis Registry.
    Ann Acad Med Singapore. 2015 Aug;44(8):290-6.
  • Chua CS, Loi CTT, Koh PK, Cheah PY, Lee HY, Tang CL, Ngeow J, Chew MH
    PTEN Hamartoma Tumour Syndrome: Gastrointestinal Manifestations of Two Cases Diagnosed in Singapore.
    Hereditary Genet 2015 4:148. doi: 10.4172/2161-1041.1000148
  • Thean LF, Wong YH, Lo M, Loi C, Chew MH, Tang CL, Cheah PY.
    Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.
    PLoS One. 2017 Mar 17;12(3):e0173772. doi: 10.1371/journal.pone.0173772
  • W Tan, J L Hamzah, S Acharyya, Foo FJ, Lim KH, I Tan BH, Tang CL, Chew MH
    Evaluation of long-term outcomes of microsatellite instability status in an Asian Cohort of Sporadic Colorectal Cancers.
    J Gastrointest Canc 2017 May 27 doi 10.1007/S12029-017-9953-6
  • Thean LF, Low YS, Michelle Lo, Teo Y-Y, Koh W-P, Yuan J-M, Chew MH, Tang CL, Cheah PY
    Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk
    J Med Genet 2018 Mar;55 (3):181–188. doi:10.1136/jmedgenet-2017-104913. Epub 2017 Oct 27. PubMed PMID: 29079706
  • Chan JY, Toh MR, Chong ST, Ishak NDB, Kolinjivadi AM, Chan SH, Lee E, Boot A, Shao-Tzu L, Chew MH, Ngeow J
    Multiple neoplasia in a patient with Gitelman syndrome harboring germline monoallelic MUTYH mutation.
    NPJ Genom Med. 2020 Sep 18;5:39. doi: 10.1038/s41525-020-00146-9. eCollection 2020.PMID: 33024574 Free PMC article.
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